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artemether/lumefantrine will raise the amount or impact of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
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clobazam decreases consequences of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Stops conversion of codeine to its Lively metabolite morphine.
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Life-threatening respiratory melancholy and Demise have occurred in children who obtained codeine; codeine is issue to check here variability in metabolism based on CYP2D6 genotype; based mostly on article-marketing experiences, young children < twelve a long time seem like additional susceptible to respiratory depressant outcomes of codeine, particularly if there are danger components for respiratory despair; scenarios of Dying are actually described while in the put up-operative interval read more pursuing tonsillectomy and/or adenoidectomy, and plenty of of the kids experienced proof of becoming extremely-swift metabolizers of codeine
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